{"id":51,"date":"2019-01-29T12:11:08","date_gmt":"2019-01-29T12:11:08","guid":{"rendered":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/?p=51"},"modified":"2019-01-29T12:11:08","modified_gmt":"2019-01-29T12:11:08","slug":"journal-club-seminar","status":"publish","type":"post","link":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/2019\/01\/29\/journal-club-seminar\/","title":{"rendered":"Journal club + Seminar"},"content":{"rendered":"<p>Please join us <strong>tomorrow 30\/01<\/strong> for the next round of the Stats reading group at SMH, with journal club + seminar sessions !<\/p>\n<p>All in the MSc students room, ground floor of SMSM building<\/p>\n<p><b>11am-midday:<\/b> Paper appraisal by students from the MSc in HDA&amp;ML: &#8220;Discovering regulatory and signalling circuits in molecular interaction networks&#8221;, T. Ideker et al, BioInformatics, 2002.<\/p>\n<p><a class=\"moz-txt-link-freetext\" href=\"https:\/\/pdfs.semanticscholar.org\/5f90\/92575e1bcafa69ab360334570166d3d8b16b.pdf\">https:\/\/pdfs.semanticscholar.org\/5f90\/92575e1bcafa69ab360334570166d3d8b16b.pdf<\/a><\/p>\n<p>In this paper, the authors propose a model for the integration of univariate associations\u00a0results with protein-protein and protein-DNA interactions stored in large and public databases. The method is based on (i) the construction of a network model using a priori knowledge on molecular interactions and (ii) the estimation of univariate z-scores representing the association of each gene with the outcome. The z-scores are then aggregated for each subnetwork in order to identify the most relevant subnetworks in association with an outcome of interest.<\/p>\n<p><b>midday-1pm: <\/b>Seminar by Benno Schwikowski, author of this week&#8217;s paper<\/p>\n<div class=\"\">Benno Schwikowski is the head of the Systems Biology group at Institut Pasteur (France). He has worked a lot with network models and in particular he developed Cytoscape (a software for network visualisation). In his seminar, he will present LEAN, a method for identification of subnetworks enriched in nodes associated with an outcome of interest.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Please join us tomorrow 30\/01 for the next round of the Stats reading group at SMH, with journal club + seminar sessions ! All in the MSc students room, ground floor of SMSM building 11am-midday: Paper appraisal by students from the MSc in HDA&amp;ML: &#8220;Discovering regulatory and signalling circuits in molecular interaction networks&#8221;, T. Ideker [&hellip;]<\/p>\n","protected":false},"author":1190,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-51","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/posts\/51","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/users\/1190"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/comments?post=51"}],"version-history":[{"count":2,"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/posts\/51\/revisions"}],"predecessor-version":[{"id":53,"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/posts\/51\/revisions\/53"}],"wp:attachment":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/media?parent=51"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/categories?post=51"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/smh-stats-reading-group\/wp-json\/wp\/v2\/tags?post=51"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}