{"id":28,"date":"2018-02-26T12:25:36","date_gmt":"2018-02-26T12:25:36","guid":{"rendered":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/?p=28"},"modified":"2018-02-26T13:13:18","modified_gmt":"2018-02-26T13:13:18","slug":"28","status":"publish","type":"post","link":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/2018\/02\/26\/28\/","title":{"rendered":"Eosinophils"},"content":{"rendered":"<p style=\"text-align: left\">This post was stimulated by a case of eosinophilic colitis I reviewed at an MDT this morning. The images are below.<\/p>\n<p style=\"text-align: left\">They show sheets of eosinophils in the lamina propria and infiltrating crypts. They are easily recognised\u00a0by their\u00a0bilobed nuclei and prominent\u00a0red granules.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"226\" class=\"size-medium wp-image-31 aligncenter\" src=\"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/files\/2018\/02\/IMG_0618-300x226.jpg\" alt=\"\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"262\" height=\"300\" class=\"size-medium wp-image-30 aligncenter\" src=\"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/files\/2018\/02\/IMG_0620-262x300.jpg\" alt=\"\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>This was an opportunity to review eosinophils.<\/p>\n<p>Eosinophils are conspicuous in inflammatory reactions triggered by IgE, such as asthma, and by parasites and are increased by T<sub>H<\/sub>-2 activation.\u00a0 IL-5 and GM-CSF increase the production of eosinophils by the bone marrow. They are associated are recruited into the tissue by eotaxins which are CC chemokines.<\/p>\n<p>Eosinophils have 2 types of effector\u00a0function:<\/p>\n<ol>\n<li>they\u00a0<em>release<\/em> toxic\u00a0granule proteins\u00a0 (e.g. major basic protein which is toxic to parasites) and free\u00a0radicals.<\/li>\n<li>they <em>synthesise\u00a0<\/em>prostaglandins, leukotrienes and cytokines.<\/li>\n<\/ol>\n<p>In the context of this case, likely causes include gut parasites, such as schistosomiasis, and allergic reactions to drugs.<\/p>\n<p>If you want to read more try the excellent British Society of Immunology Website:\u00a0https:\/\/www.immunology.org\/public-information\/bitesized-immunology\/cells\/eosinophils<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This post was stimulated by a case of eosinophilic colitis I reviewed at an MDT this morning. The images are below. They show sheets of eosinophils in the lamina propria and infiltrating crypts. They are easily recognised\u00a0by their\u00a0bilobed nuclei and prominent\u00a0red granules. &nbsp; &nbsp; &nbsp; This was an opportunity to review eosinophils. Eosinophils are conspicuous [&hellip;]<\/p>\n","protected":false},"author":1119,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290084,278892],"tags":[],"class_list":["post-28","post","type-post","status-publish","format-standard","hentry","category-gastro-intestinal-pathology","category-general-pathology"],"_links":{"self":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/posts\/28","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/users\/1119"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/comments?post=28"}],"version-history":[{"count":6,"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/posts\/28\/revisions"}],"predecessor-version":[{"id":37,"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/posts\/28\/revisions\/37"}],"wp:attachment":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/media?parent=28"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/categories?post=28"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/my-path\/wp-json\/wp\/v2\/tags?post=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}