{"id":483,"date":"2020-11-13T09:36:34","date_gmt":"2020-11-13T09:36:34","guid":{"rendered":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/?p=483"},"modified":"2020-11-13T09:37:56","modified_gmt":"2020-11-13T09:37:56","slug":"preliminary-outcomes-of-a-digital-therapeutic-intervention-for-smoking-cessation-in-adult-smokers-randomized-controlled-trial","status":"publish","type":"post","link":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/2020\/11\/13\/preliminary-outcomes-of-a-digital-therapeutic-intervention-for-smoking-cessation-in-adult-smokers-randomized-controlled-trial\/","title":{"rendered":"Preliminary Outcomes of a Digital Therapeutic Intervention for Smoking Cessation in Adult Smokers: Randomized Controlled Trial"},"content":{"rendered":"<p>Tobacco smoking remains the leading cause of preventable death and disease worldwide. Digital interventions delivered through smartphones offer a promising alternative to traditional methods, but little is known about their effectiveness. Our objective was to test the preliminary effectiveness of Quit Genius, a novel digital therapeutic intervention for smoking cessation. Our research was published in the journal <a href=\"https:\/\/mental.jmir.org\/2020\/10\/e22833\/\">JMIR Mental Health<\/a>.<\/p>\n<p>We used a 2-arm, single-blinded, parallel-group randomized controlled trial design. Participants were recruited via referrals from primary care practices and social media advertisements in the United Kingdom. A total of 556 adult smokers (aged 18\u2009years or older) smoking at least 5 cigarettes a day for the past year were recruited. Of these, 530 were included for the final analysis. Participants were randomized to one of 2 interventions. Treatment consisted of a digital therapeutic intervention for smoking cessation consisting of a smartphone app delivering cognitive behavioral therapy content, one-to-one coaching, craving tools, and tracking capabilities. The control intervention was very brief advice along the Ask, Advise, Act model. All participants were offered nicotine replacement therapy for 3 months. Participants in a random half of each arm were pseudorandomly assigned a carbon monoxide device for biochemical verification. Outcomes were self-reported via phone or online. The primary outcome was self-reported 7-day point prevalence abstinence at 4 weeks post quit date.<\/p>\n<p>556 participants were randomized (treatment: n=277; control: n=279). The intention-to-treat analysis included 530 participants (n=265 in each arm; 11 excluded for randomization before trial registration and 15 for protocol violations at baseline visit). By the quit date (an average of 16 days after randomization), 89.1% (236\/265) of those in the treatment arm were still actively engaged. At the time of the primary outcome, 74.0% (196\/265) of participants were still engaging with the app. At 4 weeks post quit date, 44.5% (118\/265) of participants in the treatment arm had not smoked in the preceding 7 days compared with 28.7% (76\/265) in the control group (risk ratio 1.55, 95% CI 1.23-1.96; P&lt;.001; intention-to-treat, n=530). Self-reported 7-day abstinence agreed with carbon monoxide measurement (carbon monoxide &lt;10 ppm) in 96% of cases (80\/83) where carbon monoxide readings were available. No harmful effects of the intervention were observed.<\/p>\n<p>We concluded that the Quit Genius digital therapeutic intervention is a superior treatment in achieving smoking cessation 4 weeks post quit date compared with very brief advice.<\/p>\n<p>DOI:\u00a0<a href=\"https:\/\/doi.org\/10.2196\/22833\">https:\/\/doi.org\/10.2196\/22833<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tobacco smoking remains the leading cause of preventable death and disease worldwide. Digital interventions delivered through smartphones offer a promising alternative to traditional methods, but little is known about their effectiveness. Our objective was to test the preliminary effectiveness of Quit Genius, a novel digital therapeutic intervention for smoking cessation. Our research was published in [&hellip;]<\/p>\n","protected":false},"author":1115,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[404],"tags":[196202],"class_list":["post-483","post","type-post","status-publish","format-standard","hentry","category-health","tag-prevention"],"_links":{"self":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/posts\/483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/users\/1115"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/comments?post=483"}],"version-history":[{"count":1,"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/posts\/483\/revisions"}],"predecessor-version":[{"id":484,"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/posts\/483\/revisions\/484"}],"wp:attachment":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/media?parent=483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/categories?post=483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/medical-centre\/wp-json\/wp\/v2\/tags?post=483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}