{"id":2745,"date":"2015-07-24T11:41:11","date_gmt":"2015-07-24T10:41:11","guid":{"rendered":"http:\/\/www2.imperial.ac.uk\/fom\/?p=2745"},"modified":"2015-07-24T11:43:14","modified_gmt":"2015-07-24T10:43:14","slug":"new-work-on-mycobacterium-tuberculosis-published-in-molecular-microbiology","status":"publish","type":"post","link":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/2015\/07\/24\/new-work-on-mycobacterium-tuberculosis-published-in-molecular-microbiology\/","title":{"rendered":"New work on Mycobacterium tuberculosis published in Molecular Microbiology"},"content":{"rendered":"<p>The ability to adapt to environments of fluctuating nutrient availability is vital for bacterial survival. In response to nitrogen limitation, Mycobacterium tuberculosis alters nitrate\/nitrite metabolism, aspartate metabolism and cell wall biosynthesis. GlnR is a key regulator involved in this response, controlling the expression of genes involved in nitric oxide detoxification and intracellular survival, markedly different to the GlnR-mediated nitrogen scavenging response seen in non-pathogenic mycobacteria. This has implications for Tuberculosis (TB) control in terms of designing new drugs to treat infection.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"685\" height=\"696\" class=\"aligncenter wp-image-2749\" src=\"https:\/\/blogs-staging.imperial.ac.uk\/fom\/files\/2015\/07\/Screen-Shot-2015-07-24-at-10.51.48-copy.jpg\" alt=\"Deciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stress\" \/><\/p>\n<p><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mmi.13091\/abstract\">DOI: 10.1111\/mmi.13091<\/a><\/p>\n<p><a href=\"http:\/\/www.imperial.ac.uk\/people\/b.robertson\">Brian D. Robertson<\/a> PhD FHEA<br \/>\n<a href=\"http:\/\/www3.imperial.ac.uk\/cmbi\">MRC Centre for Molecular Bacteriology and Infection<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The ability to adapt to environments of fluctuating nutrient availability is vital for bacterial survival. In response to nitrogen limitation, Mycobacterium tuberculosis alters nitrate\/nitrite metabolism, aspartate metabolism and cell wall biosynthesis. GlnR is a key regulator involved in this response, controlling the expression of genes involved in nitric oxide detoxification and intracellular survival, markedly different [&hellip;]<\/p>\n","protected":false},"author":919,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81],"tags":[],"class_list":["post-2745","post","type-post","status-publish","format-standard","hentry","category-research"],"_links":{"self":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/posts\/2745","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/users\/919"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/comments?post=2745"}],"version-history":[{"count":5,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/posts\/2745\/revisions"}],"predecessor-version":[{"id":2754,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/posts\/2745\/revisions\/2754"}],"wp:attachment":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/media?parent=2745"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/categories?post=2745"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/tags?post=2745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}