{"id":1057,"date":"2013-06-27T11:55:29","date_gmt":"2013-06-27T10:55:29","guid":{"rendered":"http:\/\/www2.imperial.ac.uk\/fom\/?p=1057"},"modified":"2018-05-29T10:38:01","modified_gmt":"2018-05-29T09:38:01","slug":"a-role-for-a-tumour-suppressor-in-prostate-gland-architecture","status":"publish","type":"post","link":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/2013\/06\/27\/a-role-for-a-tumour-suppressor-in-prostate-gland-architecture\/","title":{"rendered":"A role for a tumour suppressor in prostate gland architecture"},"content":{"rendered":"<figure id=\"attachment_1059\" aria-describedby=\"caption-attachment-1059\" style=\"width: 229px\" class=\"wp-caption alignright\"><a href=\"http:\/\/www2.imperial.ac.uk\/fom\/files\/2013\/06\/Kypta.png\"><img loading=\"lazy\" decoding=\"async\" width=\"424\" height=\"424\" class=\"size-full wp-image-1059  \" src=\"http:\/\/www2.imperial.ac.uk\/fom\/files\/2013\/06\/Kypta.png\" alt=\"Disorganised region of a prostate gland\" \/><\/a><figcaption id=\"caption-attachment-1059\" class=\"wp-caption-text\">Disorganised region of a prostate gland from a Dkk-3 mutant mouse showing E-cadherin in green, ZO1 in red and nuclei in blue<\/figcaption><\/figure>\n<p>Researchers from the <a href=\"http:\/\/www1.imperial.ac.uk\/surgeryandcancer\/\">Department of Surgery and Cancer<\/a> have uncovered a novel link between the tumour suppressor Dickkopf-3 (Dkk-3) and <a href=\"http:\/\/en.wikipedia.org\/wiki\/TGF_beta_signaling_pathway\">TGF-\u03b2\u00a0signalling<\/a>. The team previously found that <a href=\"http:\/\/www.nature.com\/onc\/journal\/v25\/n49\/abs\/1209661a.html\">Dkk-3 is required for human prostate epithelial cells to form acinar structures in 3D matrigel cultures<\/a>; an<em> in vitro<\/em> model for prostate gland development.<\/p>\n<p>This new study, carried out in collaboration with the <a href=\"http:\/\/www.cicbiogune.es\/\">Centre for Cooperative Research in Biosciences<\/a> (CIC bioGUNE) in Bilbao and the <a href=\"http:\/\/www.dkfz.de\/en\/index.html\">German Cancer Research Center<\/a> (DKFZ) in Heidelberg, shows that Dkk-3 limits epithelial cell proliferation in 3D cultures and during mouse prostate gland development. It is well known that TGF-\u03b2 signals go awry during cancer progression; switching from tumour suppression to tumour promotion. This study shows that loss of Dkk-3 activates TGF-\u03b2 signalling &#8211; inhibition of which rescues the 3D phenotype.<\/p>\n<p>The results provide further support and rationale for the use of TGF-\u03b2 inhibitors to treat prostate cancer. They may also be relevant to other cancers, such as those of the breast and the ovary, where similar changes in Dkk-3 and the TGF-\u03b2 response take place. The studies at Imperial were carried out by Diana Romero and Yoshiaki Kawano, now at <a href=\"http:\/\/ewww.kumamoto-u.ac.jp\/\">Kumamoto University<\/a> in Japan, and were funded by a <a href=\"http:\/\/www.cancerresearchuk.org\/\">Cancer Research UK<\/a> (CRUK) Project Grant awarded to <a href=\"http:\/\/www1.imperial.ac.uk\/medicine\/people\/r.kypta\/\">Robert Kypta<\/a> and <a href=\"http:\/\/www1.imperial.ac.uk\/medicine\/people\/j.waxman\/\">Jonathan Waxman<\/a>.<\/p>\n<p><a href=\"http:\/\/jcs.biologists.org\/content\/early\/2013\/02\/21\/jcs.119388\">The work is published in the Journal of Cell Science<\/a>.<\/p>\n<p><strong><a href=\"http:\/\/www1.imperial.ac.uk\/medicine\/people\/r.kypta\/\">Dr Robert M Kypta<\/a><\/strong><br \/>\nLecturer in Prostate Cancer<br \/>\nDepartment of Surgery &amp; Cancer<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the Department of Surgery and Cancer have uncovered a novel link between the tumour suppressor Dickkopf-3 (Dkk-3) and TGF-\u03b2\u00a0signalling. The team previously found that Dkk-3 is required for human prostate epithelial cells to form acinar structures in 3D matrigel cultures; an in vitro model for prostate gland development. This new study, carried out [&hellip;]<\/p>\n","protected":false},"author":629,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81],"tags":[],"class_list":["post-1057","post","type-post","status-publish","format-standard","hentry","category-research"],"_links":{"self":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/posts\/1057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/users\/629"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/comments?post=1057"}],"version-history":[{"count":9,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/posts\/1057\/revisions"}],"predecessor-version":[{"id":4268,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/posts\/1057\/revisions\/4268"}],"wp:attachment":[{"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/media?parent=1057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/categories?post=1057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs-staging.imperial.ac.uk\/fom\/wp-json\/wp\/v2\/tags?post=1057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}